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Mostrando ítems 1-17 de 17

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      Acute and Chronic Sustained Hypoxia Do Not Substantially Regulate Amyloid-β Peptide Generation In Vivo 

      Serrano Pozo, Alberto; Sánchez García, Manuel A.; Heras Garvín, Antonio; March Díaz, Rosana Rocío; Navarro Garrido, Victoria; Vizuete Chacón, María Luisa; López Barneo, José; Vitorica Ferrández, Francisco Javier; Pascual, Alberto (Public Library of Science, 2017)
      Background Recent epidemiological evidence has linked hypoxia with the development of Alzheimer disease (AD). A number ...
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      Amyloid-β impairs the phagocytosis of dystrophic synapses by astrocytes in Alzheimer's disease 

      Sánchez Mico, María; Jiménez Muñoz, Sebastián; Gómez Arboledas, Ángela; Muñoz Castro, Clara; Romero Molina, Carmen; Navarro Garrido, Victoria; Vizuete Chacón, María Luisa; Vitorica Ferrández, Francisco Javier (Wiley, 2020)
      Reactive astrocytes and dystrophic neurites, most aberrant presynaptic elements, are found surrounding amyloid-β plaques ...
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      Blockade of the Interaction of Calcineurin with FOXO in Astrocytes Protects Against Amyloid-βInduced Neuronal Death 

      Navarro Garrido, Victoria; Vitorica Ferrández, Francisco Javier; Fernández, Ana M.; Hervasa, Rubén; Gómez Gutiérrez, Patricia; Vega, Miguel (IOS Press, 2016)
      Astrocytes actively participate in neuro-inflammatory processes associated to Alzheimer’s disease (AD), and other brain ...
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      Defective lysosomal proteolysis and axonal transport are early pathogenic events that worsen with age leading to increased APP metabolism and synaptic Abeta in transgenic APP/PS1 hippocampus 

      Gutiérrez Pérez, Antonia; Vitorica Ferrández, Francisco Javier; Dávila Cansino, José Carlos; Vizuete Chacón, María Luisa; Carmona Cuenca, Irene; Jiménez Muñoz, Sebastián; Trujillo Estrada, Laura Isabel; Sánchez Varo, Raquel María; Torres Canalejo, Manuel; Sánchez Mejías, Elisabeth; Navarro Garrido, Victoria (2012)
      Background: Axonal pathology might constitute one of the earliest manifestations of Alzheimer disease. Axonal dystrophies ...
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      Disruption of Amyloid Plaques Integrity Affects the Soluble Oligomers Content from Alzheimer Disease Brains 

      Jiménez Muñoz, Sebastián; Navarro Garrido, Victoria; Moyano González, Francisco Javier; Sánchez Mico, María; Torres Canalejo, Manuel; Dávila Cansino, José Carlos; Vizuete Chacón, María Luisa; Gutiérrez Pérez, Antonia; Vitorica Ferrández, Francisco Javier (Public Library of Science, 2014)
      The implication of soluble Abeta in the Alzheimer's disease (AD) pathology is currently accepted. In fact, the content of ...
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      Distinct Microglial Responses in Two Transgenic Murine Models of TAU Pathology 

      Romero Molina, Carmen; Navarro Garrido, Victoria; Sánchez Varo, Raquel María; Jiménez Muñoz, Sebastián; Fernández Valenzuela, Juan José; Sánchez Mico, María; Muñoz Castro, Clara; Gutiérrez Pérez, Antonia; Vitorica Ferrández, Francisco Javier; Vizuete Chacón, María Luisa (Frontiers Media Research Foundation, 2018-11-14)
      Microglial cells are crucial players in the pathological process of neurodegenerative diseases, such as Alzheimer’s disease ...
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      Dual roles of Aβ in proliferative processes in an amyloidogenic model of Alzheimer’s disease 

      Baglietto Vargas, David; Sánchez Mejías, Elisabeth; Navarro Garrido, Victoria; Jiménez Muñoz, Sebastián; Trujillo Estrada, Laura Isabel; Gómez Arboledas, Ángela; Sánchez Mico, María; Sánchez Varo, Raquel María; Vizuete Chacón, María Luisa; Dávila Cansino, José Carlos; García Verdugo, José Manuel; Vitorica Ferrández, Francisco Javier; Gutiérrez Pérez, Antonia (Nature Research (part of Springer Nature), 2017)
      Alzheimer’s disease is a major neurodegenerative disorder that leads to severe cognitive deficits in the elderly population. ...
    • Trabajo Fin de Grado
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      Factores de riesgos genético en la enfermedad de alzheimer esporádico 

      García Gamarro, Paula (2019-06)
      La enfermedad de Alzheimer (EA) se ha convertido en una gran preocupación para la población mundial, ya que produce una ...
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      Galectin‑3, a novel endogenous TREM2 ligand, detrimentally regulates infammatory response in Alzheimer’s disease 

      Boza Serrano, Antonio; Ruíz Laza, Rocio; Sánchez Varo, Raquel María; García Revilla, Juan; Yang, Yiyi; Jiménez Ferrer, Itzia; Jiménez Muñoz, Sebastián; Roca Ceballos, María Angustias; Navarro Garrido, Victoria; Vitorica Ferrández, Francisco Javier; Venero Recio, José Luis; Deierborg, Tomas (Springer, 2019)
      Alzheimer’s disease (AD) is a progressive neurodegenerative disease in which the formation of extracellular aggregates of ...
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      Hypoxia compromises the mitochondrial metabolism of Alzheimer’s disease microglia via HIF1 

      March Diaz, Rosana; Lara Ureña, Nieves; Romero Molina, Carmen; Heras Garvin, Antonio; Ortega de San Luis, Clara; Alvarez Vergara, Maria I.; Navarro Garrido, Victoria; Sánchez Mico, María Victoria; Vizuete Chacón, María Luisa; López Barneo, José; Vitorica Ferrández, Francisco Javier; Pascual, Alberto (Springer, 2021)
      Genetic Alzheimer’s disease (AD) risk factors associate with reduced defensive amyloid β plaque-associated microglia (AβAM), ...
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      In vivo modification of Abeta plaque toxicity as a novel neuroprotective lithium-mediated therapy for Alzheimer’s disease pathology 

      Trujillo Estrada, Laura Isabel; Jiménez Muñoz, Sebastián; Castro, Vanessa de; Torres Canalejo, Manuel; Baglietto Vargas, David; Moreno González, Inés; Navarro Garrido, Victoria; Sánchez Varo, Raquel María; Sánchez Mejías, Elisabeth; Dávila Cansino, José Carlos; Vizuete Chacón, María Luisa; Gutiérrez Pérez, Antonia; Vitorica Ferrández, Francisco Javier (BioMed Central, 2013)
      Background: Alzheimer’s disease (AD) is characterized by the abnormal accumulation of extracellular beta-amyloid (Abeta) ...
    • Ponencia
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      Litio como terapia neuroprotectora en el modelo appsl/ps1m146l de la enfermedad de Alzheimer 

      Trujillo Estrada, Laura Isabel; Castro, Vanesa de; Jiménez Muñoz, Sebastián; Sánchez Varo, Raquel María; Sánchez Mejías, Elisabeth; Navarro Garrido, Victoria; Vizuete Chacón, María Luisa; Dávila Cansino, José Carlos; Vitorica Ferrández, Francisco Javier; Gutiérrez Pérez, Antonia (2013)
      El litio se utiliza desde hace varias décadas en el tratamiento de trastornos bipolares y la depresión, y recientemente se debate su uso potencial en patologías neurodegenerativas como la enfermedad de Alzheimer (AD).
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      Microglia in Alzheimer’s Disease: Activated, Dysfunctional or Degenerative 

      Navarro Garrido, Victoria; Sánchez Mejías, Elisabeth; Jiménez Muñoz, Sebastián; Muñoz Castro, Clara; Sánchez Varo, Raquel María; Dávila, José Carlos; Vizuete Chacón, María Luisa; Gutiérrez, Antonia; Vitorica Ferrández, Francisco Javier (Frontiers Media, 2018)
      Microglial activation has been considered a crucial player in the pathological process of multiple human neurodegenerative ...
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      Monocyte-derived Cells Invade Brain Parenchyma and Amyloid Plaques in Human Alzheimer’s Disease Hippocampus 

      Muñoz-Castro, Clara; Mejías Ortega, Marina; Sánchez Mejías, Elisabeth; Navarro Garrido, Victoria; Trujillo Estrada, Laura; Jiménez, Sebastián; García León, Juan Antonio; Fernández Valenzuela, Juan José; Sánchez Mico, María Virtudes; Romero Molina, Carmen; Moreno González, Inés; Baglietto Vargas, David; Vizuete Chacón, María Luisa; Gutiérrez, Antonia; Vitorica Ferrández, Francisco Javier (Springer Nature, 2023)
      Microglia are brain-resident myeloid cells and play a major role in the innate immune responses of the CNS and the ...
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      Phagocytic clearance of presynaptic dystrophies by reactive astrocytes in Alzheimer's disease 

      Gómez Arboledas, Ángela; Dávila Cansino, José Carlos; Sánchez Mejías, Elisabeth; Navarro Garrido, Victoria; Núñez Díaz, Cristina; Sánchez Varo, Raquel María; Sánchez Mico, María; Vizuete Chacón, María Luisa; Vitorica Ferrández, Francisco Javier; Gutiérrez Pérez, Antonia (Wiley, 2018)
      Reactive astrogliosis, a complex process characterized by cell hypertrophy and upregulation ofcomponents of intermediate ...
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      Should we open fire on microglia? Depletion models as tools to elucidate microglial role in health and alzheimer’s disease 

      Romero Molina, Carmen; Navarro Garrido, Victoria; Jiménez Muñoz, Sebastián; Muñoz Castro, Clara; Sánchez Mico, María; Gutiérrez, Antonia; Vitorica Ferrández, Francisco Javier; Vizuete Chacón, María Luisa (Multidisciplinary Digital Publishing Institute (MDPI), 2021)
      Microglia play a critical role in both homeostasis and disease, displaying a wide variety in terms of density, functional ...
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      Soluble phospho‑tau from Alzheimer’s disease hippocampus drives microglial degeneration 

      Sánchez Mejías, Elisabeth; Navarro Garrido, Victoria; Jiménez Muñoz, Sebastián; Sánchez Mico, María; Sánchez Varo, Raquel María; Núñez Díaz, Cristina; Trujillo Estrada, Laura Isabel; Dávila, José Carlos; Vizuete Chacón, María Luisa; Gutiérrez, Antonia; Vitorica Ferrández, Francisco Javier (Springer (part of Springer Nature): Springer Open Choice Hybrid Journals, 2016)
      The role of microglial cells in the development and progression of Alzheimer’s disease (AD) has not been elucidated. Here, ...